![]() Taipale at Karolinska Institute (Jolma et al., Cell 152, 327-339 (2013) PubMed 23332764) and were kindly provided by P. The logo plots after many TF genera have been derived from the profile library published by the group of J. ![]() They should not be taken as a consensus, and they are not suitable for predicting potential TF binding sites. The DNA sequences assigned to many families or subfamilies represent typical or proven individual binding sequences for (some of) the domains in the respective taxon. The question mark in the Class title line links to the class description, the sequences of the manually adjusted DNA-binding domains of this respective class and their alignments, logo plots and, whenever relevant, further information like dimerization matrices etc. : Link to PDB preferably to a complex of the corresponding DNA-binding domain (DBD) with DNA, provisionally the DBD alone, referring to the human or a mammalian ortholog for a few excpetions, illustrative structures of fungal homologs are linked. "Txxxxx": TRANSFAC accession numbers, mostly linked to BIOBASE Knowledge Library (BKL) "T" only provides a link to a BKL entry that has no TRANSFAC accession yet. ![]() : Link to reviewed mouse entries UniProt : Link to unreviewed mouse entries UniProt : Link to reviewed human UniProt entries / : Link to reviewed/unreviewed rat UniProt entries, resp. : TRANSFAC® class descriptions : new class descriptions : additional information about the class and its members (see below) As for the classification of the human TFs, it may be subject to occasional changes, suggested for discussion. ![]() In particular many mouse-specific TFs are still missing in Class 2.3 (C2H2 zinc finger factors). This classification is the working version that comprises only murine transcription factors (TFs) that have human orthologs, with few exceptions. Mouse TF classification Classification of Mouse Transcription Factors ![]()
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